On November 1, 2021, Japan announced to revise the “Directory Distinguishing Food and Drug Ingredients” (hereinafter “the directory”). According to the revision, a total of five new ingredients have been added into the directory, and three ingredients have been revised. Details are as follows:
Appendix 1 substances specialized for pharmaceuticals
Name | Alias | Part | Remark |
ピリミデナフィル(Pyrimidenafil) | Pyrimidenafil | / | Added |
Pseudoephedrine | / | / | Added |
Ephedra | / | Terrestrial stem | Extracts from which plant bases have been removed by methods such as cation exchange are "non-medical" |
Glutathione | Reduced glutathione | / | The alias was added |
Appendix 2 ingredients that can be used as common food ingredients as long as they do not claim medicinal efficacy
Name | Alias | Part | Remark |
Oroxylum indicum | オオナタノミノキ | Bark | Added |
Rhodomyrtus | Myrtle | Fruit | Added |
L-エルゴチオネイン (L-Ergothioneine) | L-Ergothioneine | / | Added |
Salacia oblonga | / | Stem, root | Added the stem part |
We provide full-scale global food market entry services (including product registration, ingredient review, regulatory consultation, customized training, market research, branding strategy). Please contact us to discuss how we can help you by 
